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Secondary bile acids (lithocholic acid and deoxycholic acid) are its most potent agonists (73)

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These results were obtained primarily through questionnaires (State-Trait Anxiety Inventory (STAI), Pittsburgh Sleep Quality Index (PSQI), Short Form Health Survey (SF-8), Gastrointestinal Symptom Rating Scale (GSRS), Oguri–Shirakawa–Azumi sleep, Visual Analogue Scale) to evaluate somatic symptoms, computerized tests (neurocognitive function tests (CNT) to measure cognitive impairment, screening tests specifically designed for older adults to assess depressive symptoms while excluding somatic ones, and self-report scales (SAS-SDS) that measure anxiety levels based on affective and somatic symptoms