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Research published in the Journal of Biological Chemistry established that GHK-Cu upregulates TGF-β1 and TGF-β2 expression in fibroblast models while simultaneously suppressing TGF-β-induced Smad3 phosphorylation under inflammatory conditions

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First isolated in 1974 by Swiss researchers Schoenenberger and Monnier from the cerebral venous blood of rabbits during electrically induced slow-wave sleep, DSIP was the first endogenous peptide identified specifically in the context of sleep regulation

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