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Clinical experience: Nasal glucagon (Baqsimi) is feasible for rescue indications, with bioavailability of approximately 30%–40%, rapid onset suitable for hypoglycemia rescue, and needle-free administration important for caregivers treating unconscious patients ( Best fit: Very potent peptides requiring small doses, rescue medications where needle-free administration is valuable (hypoglycemia, opioid overdose), or CNS-targeted strategies where direct nose-to-brain access may offer advantages over systemic administration

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Singer MA, Lazaridis C, Nations SP, Wolfe GI

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