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Although the underlying mechanisms for esophageal hypersensitivity remain unclear, RH patients typically experience more frequently weakly acidic reflux events, heightened sensitivity compared to those with FH, and a greater incidence of proximal reflux, factors that may contribute to their symptoms

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An emerging aspect of circRNA function involves the assembly of ribonucleoprotein (RNP) complexes through their scaffold-like capacity to coordinate RBPs and mRNA substrates [45, 51]