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A nanocoating Co-localizing nitric oxide and growth factor onto individual endothelial cells reveals synergistic effects on angiogenesis

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In terms of metalloproteinase regulation, ROS can lead to the inactivation of tissue inhibitors, promoting the formation of a proteolytic microenvironment in chronic wounds (97), and induce the expression of matrix metalloproteinases in fibroblasts, especially under the exposure to singlet oxygen (98), hydrogen peroxide (99), or hydroxyl radicals (100)