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Amino acids are hydrophilic because they contain carboxylic and amino groups

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The insulin signaling network in metabolically compromised adipocytes manifests multiple molecular defects: impaired IR activation kinetics, substantial reduction in IRS-1 tyrosine phosphorylation, marked suppression of PI3K/Akt pathway signal propagation, and pathological elevation of inhibitory serine phosphorylation events on IRS-1 (66)