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Foreign drugs such as resveratrol, fexaramine, rapamycin, and UMI-77 can also be administered to stimulate the mitophagy pathway to enhance cytoprotective effects and antagonize cisplatin ototoxicity (Figure 1

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This step is required for recruitment of adaptor molecules such as Fas-associated protein with a death domain and the subsequent activation of caspase-8, ultimately driving apoptosis [45,46]