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IGF-1 has little effect on the adipocyte and mature liver due to a lack of IGF-1 receptors at these sites, but recombinant human IGF-1 has been shown to overwhelm hepatic glucose production via unknown mechanisms, and recombinant human IGF-1 therapy has proved efficacious in patients with severe IR [50]

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E.La GrenadeL.BurgessM.et al (2007)