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Glutamate can be reversibly transaminated to α-ketoglutarate via glutamate dehydrogenase (GDH) or transaminases such as aspartate aminotransferase, allowing for both the clearance of excess synaptic glutamate and the replenishment of TCA cycle intermediates

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They could be a consideration for someone whose routine includes regular movement, balanced meals, and attention to long-term cellular care, though supplements work best as one part of a broader lifestyle rather than as a substitute for varied nutrition, rest, hydration, or professional guidance