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Interestingly, mutations in components of the MEKK1‐MKK1/MKK2‐MPK4 cascade produce constitutive autoimmune responses very similar to those observed in tomato and cotton Gβ mutants and were mistakenly considered negative regulators of the defense response until the discovery of SUMM2 established that they are in fact positive regulators of the PTI response (Zhang et al., 2012)