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in oncology, it targets the host cell’s machinery, whereas in infectious diseases, it must directly interact with the pathogen or disrupt the host-pathogen interaction, frequently resulting in pharmacological discrepancies in cytotoxic effects (Mugenyi, 2025)

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In AD models, phospho-tau colocalizes with lipid rafts enriched in polyunsaturated fatty acids, and ω-6 fatty acids such as arachidonic acid have been shown to promote tau oligomerization (128, 129)