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Further supporting this notion of the bidirectional relationship between age and sleep-wake disruption, studies have noted that behavioral or genetic manipulation of circadian rhythms also causes aging-like phenotypes (Hood and Amir, 2017)

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Bei unsachgemäßer Dosierung kann es zu einer Überreaktion mit verstärkter Tagesmüdigkeit kommen, weshalb eine individuelle Dosisanpassung wichtig ist