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For instance, accumulated succinate acts as a competitive inhibitor of α-KG–dependent dioxygenases, including the ten-eleven translocation (TET) family of DNA demethylases and Jumonji C domain-containing (JMJD) family histone demethylases, thereby promoting global DNA hypermethylation and transcriptional silencing [51]

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Laboratory assessment of severe chronic active liver disease during and after corticosteroid therapy: correlation of serum transaminase and gamma globulin levels with histologic features