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Border Collie Several case reports and case series have described a selective cobalamin malabsorption in the Border Collie breed.18, 75, 76, 78 Clinical manifestations in some cases are mild and the onset of clinical signs can be delayed into early adulthood compared to other breeds with selective cobalamin malabsorption.17, 75 Also, juvenile cobalamin deficiency might not be routinely associated with hematologic changes in the Border Collie breed.18, 75, 76 About 40% of healthy Border Collies have increased urine MMA levels,6 but none of the normocobalaminemic dogs in that study had increased plasma HCY concentrations compared to the Border Collies with cobalamin deficiency