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The multifaceted nature of PD comorbidities necessitates a precision medicine approach tailored to the patient’s full clinical context ( 4.1 Neuropsychiatric symptoms: depression, anxiety, and cognitive decline Over 40–60% of PD patients experience depression and anxiety, which are often underdiagnosed and misattributed to motor disability ( Cognitive impairment, ranging from mild cognitive dysfunction to Parkinson’s disease dementia (PDD), affects up to 80% of individuals in advanced stages (25)