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Recent reviews and experimental studies suggest that the ECM is not simply a passive scaffold: polysaccharides of the matrix and matrix-associated proteins actively bind small molecules and drugs, and matrix-derived extracellular vesicles provide additional enzymatic and structural factors that stabilize the integrity of the matrix (Roy and Gow, 2023
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Natural sesquiterpene lactones as inhibitors of Myb-dependent gene expression: structure-activity relationships