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doi: 10.1152/ajpendo.1998.275.2.E359

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Destructive cholangitis is characterized histopathologically by a loss of bile ducts (ductopenia) within the smaller portal areas, associated with cholestasis, portal inflammation consisting primarily of macrophages, neutrophils, and occasionally eosinophils, and progressive portal fibrosis.1, 31, 32 This is a rarely reported lesion of unknown etiology