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Synergism • when two receptors produce a combined effect that is greater than the sum of their individual effect

potency

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The unfortunate truth is that big risk signals (let’s say the kind you get from drinking antifreeze) can be spotted from the anecdotal experience of people in the world just trying things, but small-but-serious risk signals (let’s say cardiovascular disease with tofacitinib) are really hard to identify without a proper trial or a proper observational study