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69 compared GSH blood concentrations in healthy young and healthy elderly subjects and found that the reference group of 20- to 39-year-old subjects (n = 40) had a GSH concentration 17% higher on average than the 60- to 79-year-old cohort of 60 subjects (mean ± SD, 547 ± 53.5 g/10 10 vs

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Importantly, these pathways exhibit significant cross-talk, forming an integrated signaling network that underlies the overlapping cardioprotective effects of structurally diverse natural bioactive compounds (Wardyn et al., 2015) (Table 3)