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Acid keeps the protein away from the pH at which its net charge is lowest and aggregation is most favorable, but it also means the concentrated stock is not at physiological pH and that transferring it into a buffered medium involves a pH transition where local precipitation can occur if it is done abruptly into a small volume

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She also stressed the need for collaboration with churches, community health centers, and other local organizations to enhance recruitment and retention of racially and ethnically diverse volunteers, who have traditionally been underrepresented in clinical trials

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