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Foundational clinical and mechanistic literature (2021–2022) The SURPASS-1 through SURPASS-5 trials, published across NEJM and The Lancet in 2021–2022, characterised tirzepatide's glycaemic and weight outcomes versus placebo, semaglutide, insulin degludec, and insulin glargine at doses up to 15 mg once weekly [9]

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LIPUS promotes synthesis and secretion of extracellular matrix and reduces cell apoptosis in human osteoarthritis through upregulation of SOX9 expression