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B12 supports red blood cell formation and DNA synthesis, so low levels can matter even when signs are subtle

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The Regulatory Impact Analysis of the HEBA from the CY 2025 PFS final rule (89 FR 98523 and 98524) estimated that total net savings is projected to grow over ten years by approximately $260 million as a result of the HEBA attracting additional high-cost ACOs to join the program and creating savings for the Medicare program, ranging from a $1.2 billion cost to a $2.2 billion savings at the 10th and 90th percentiles