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This finding was confirmed by a later [ 11 C](R)-PK11195-PET study, wherein they investigated TSPO levels in a cohort of medication-free patients in a major depressive episode of at least moderate severity that was compared with matched healthy subjects

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Subsequent PET imaging experiments in murine models of HER2-positive human epidermoid carcinoma revealed that the administration of urokinase dramatically improved the radioimmunoconjugate’s tumor-to-blood activity concentration ratios, yielding contrast at 24 h comparable to that achieved at 72 h with traditional radioimmunoconjugates (Figure )