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A 2025 case report describes systemic inflammatory response syndrome after a high-dose unregulated intravenous glutathione infusion given for skin lightening: shock, hyperpyrexia above 41 C, white cell count 26 x 10^9/L, CRP 160 mg/L, procalcitonin 28.8 micrograms/L, ALT 311 IU/L and prothrombin time 26.4 seconds, with no infectious source found and full recovery on supportive care

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