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The effects of treatment with individual inhibitors of Met, PDK1, MEK, and PI3K on pAKt and pERK and with combinations of Met + PDK1 and MEK + PI3K inhibitors were measured in a previous study

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The NIA Interventions Testing Program (ITP) reported modest lifespan extension in male mice treated with astaxanthin, even with treatment initiated at 12 months of age (Harrison et al., 2024), a time point when significant molecular damage from early development has already accumulated, potentially limiting beneficial effects