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Finally, a recent 2021 study performed in a paediatric population (0–3 years) in Turkey found that a sublingual methyl-Cbl treatment regimen, comprising 1 mg daily replacement for a week followed by every other day for 2 weeks, 2 days/week for 2 weeks and once a week for 3 months was as effective as similar dose schedules of IM and oral CN-Cbl at normalising B12 levels ( Although these studies report promising results regarding the sublingual route, it is important to note that almost all of them only include patients with mild, subclinical B12 deficiency, making it difficult to extrapolate their outcomes for patients with severe deficiency or malabsorptive states