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Furthermore, in mouse and human prostate cancer organoids models, inhibition of EZH2 also increases the expression of the Th1 attracting chemokines CXCL9 and CXCL10 as well as Th1 cytokines including IL-2 and IL-12, which enhances CD4 + and CD8 + T cells infiltration in the TME and sensitizes prostate cancer to anti-PD1 therapy (117)

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