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As a triple agonist , it simultaneously activates three distinct receptor systems [5]: GIP (Glucose-dependent Insulinotropic Polypeptide) receptors – enhance insulin secretion and may have direct effects on adipose tissue GLP-1 (Glucagon-like Peptide-1) receptors – promote satiety, slow gastric emptying, and improve glucose regulation Glucagon receptors – increase energy expenditure and may enhance fat oxidation This multi-receptor targeting strategy distinguishes retatrutide from single-pathway peptides and creates a complex metabolic profile that researchers are still working to fully characterize