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These processes commonly result in increased bioavailability of ROS due to excess ROS formation, decreased nitric oxide (NO) levels, and impaired antioxidant capacity in the arteries, heart, brain, and kidneys (133, 134)

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10.1001/jama.2013.280777 174 LazzeriniM.MartelossiS.MagazzuG.PellegrinoS.LucantoM