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Profile B — Normal CYP1B1 · Val/Val COMT · C/C MTHFR · Arg/Arg SULT1A1 · GSTM1 present · Low ESR1 sensitivity: Phase 1 generates a favorable 2-OHE2:4-OHE2 ratio

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For example, β-naphtoflavone, a planar aromatic xenobiotic, modulates γ-glutamate-cysteine ligase in the liver cell line HepG2 through TRE/AP1 and ARE [95]