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Interestingly, the effect of AMG on translation was enhanced during selenium restriction, suggesting that under conditions of adequate selenium, the presence of cofactors involved in Sec incorporation may protect against AMG-induced misincorporation

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When it binds with copper (Cu²⁺), it activates enzymes responsible for: connective tissue formation antioxidant defense cellular respiration It also regulates free copper ions to prevent oxidative stress, keeping the system balanced rather than reactive