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this is a medical emergency Perforation of the bowel wall in severe disease Severe dehydration from prolonged diarrhoea Longer-term complications Iron-deficiency anaemia and other nutritional deficiencies Bone thinning (osteopenia and osteoporosis), particularly with repeated steroid courses Higher risk of blood clots during flares Higher risk of colorectal cancer with long-standing extensive disease Primary sclerosing cholangitis (PSC), a liver disease that affects a small minority of people with UC Living with Ulcerative Colitis Beyond the medical details, much of what shapes life with UC is practical: how to plan a day, how to travel, how to talk about the condition at work, and how to manage the social side of an illness that is largely invisible