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Complex I (site I Q ) and Complex III (site Q o ) are subjected to single-electron leakage under conditions of high membrane potential or reverse electron transport (RET), directly reducing O 2 to •O 2 − in mitochondria (Fig

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Acceleration of glutathione efflux and inhibition of γ- glutamyltranspeptidase sensitize metastatic B16 melanoma cells to endothelium-induced cytotoxicity