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In Phase I clinical trials, SYNB1891 demonstrated significant activation of the STING pathway but resulted in four cases (4/28) of cytokine release syndrome events ( 3 pH-responsive nanoplatforms The TME comprises stromal cells, immune cells, fibroblasts, growth factors, blood vessels, and extracellular matrix components, collectively forming the primary structural and functional foundation of solid tumors alongside tumor cells ( 3.1 pH-responsive carrier-free nanoplatform pH-responsive carrier-free nanoplatforms are typically constructed through non-covalent interactions (such as electrostatic interactions, hydrogen bonds, and van der Waals forces) and acid-sensitive labile bonds (such as coordination bonds) ( 3 through the formation of RA–Fe 3+ coordination bonds
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The chemical's XRD data show that crystal orientation preference already exists at the earliest stages of molecule formation
