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In all five studies, authors investigated the effects of HBO preconditioning on postischemic AKI [36,37,38,39,40]

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2.3.2 Dysfunction of mitochondrial energy metabolism A reduction in the expression of peroxisome proliferator-activated receptor alpha (PPARα), a key regulator of FA homeostasis, has been associated with decreased activity of carnitine palmitoyltransferase 1 (CPT1), thereby impairing the transport of FAs into the mitochondrial matrix ( Glycolysis may briefly enhance energy production and offer partial protective effects in the setting of AKI, but its prolonged activation has been linked to adverse renal outcomes