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The release of genomic DNA into the cytosol activates cyclic GMP–AMP synthase, which is accompanied by the activation of nuclear factor kappa-light-chain enhancer of activated B cells (NF-κB) signaling (Bakhoum et al

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Discussion: Overall, this study demonstrates the use of CPZ and LPC to model either acute or prolonged demyelination in a sagittal organotypic brain slice culture system