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Unfortunately, clinical trials with anti-cytokine therapies such as Anakinra, an IL-1 receptor antagonist, were not efficacious in delaying T1D, suggesting a more complex interaction between cytokines and beta-cells in vivo ( Figure 3 Beta-Cell Heterogeneity It is challenging to fully understand the response and contribution of the beta-cell to the T1D disease state without understanding beta-cell heterogeneity