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The first chemical entities that are formed under the activity of LOX are the divalent immature molecules dihydroxylysinornorleucine (DHLNL) and hydroxylysinonorleucine (HLNL), which then with maturation are transformed to trivalent crosslinks pyrdinoline (PYD), deoxypyridinoline (DPD) and pyrrolic analogues (Figure 1)