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46 Concentrations range from 0.01 to 0.1% and tretinoin can be formulated in creams, gels, and microsphere gels, which allows for the controlled release of tretinoin leading to less irritation

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Currently, the commonly used cationic antibacterial agents have some limitations in biomedical applications, such as toxicity (such as Ag + ) and high cost (such as specially designed antimicrobial peptides) (Wei et al., 2021)