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Although increased synthesis of pro-inflammatory cytokines such as IL-1β, IL-6, IL-18 and TNFα, accompanied by rising levels of anti-inflammatory cytokines including IL-8, IL-10 and production of chemokines such as MCP1 and CCL5 has been attributed to activate blood-borne and CNS-resident immune cells, notably neutrophils, microglia and T-cells [21]