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Multidimensional experimental validation studies have shown that, in fibrotic myocardial tissues from patients with myocardial infarction and also on the basis of TGF-β1-induced in vitro models, myocardial fibroblasts exhibit upregulated METTL1 expression levels (which are elevated compared with controls) and a significant increase in the abundance of transcriptome-wide m7G methylation (143)

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[DOI] [PubMed] [Google Scholar] 118.Wang W., Guan C., Sun X