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Genistein triggers ER stress and activates calpain 1, which sequentially promotes Bcl-2 associated X-protein (Bax) and BH3 interacting domain death agonist (Bid) cleavage and the translocation to active Bax and t-Bid to mitochondria followed by the cytosolic release of cytochrome C and apoptosome formation

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Similar to other published results, the authors showed that cascades of events leading to apoptosis, which involved anti-proliferation, chromatin condensation and DNA fragmentation was evident in curcumin, bisdemethoxycurcumin and demethoxycurcumin teatments, with the latter demonstrating superior activity compared to the other compounds