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IGFBP-3 proteolysis has also been described in insulin resistant states such as fasting, obesity and type 1 and 2 diabetes (62, 124, 125)

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In recent years, the role of HIV transcripts in mediating microglial activation has garnered significant attention as a research hotspot in the progression of NeuroHIV, primarily due to their strong induction and sustainment of the inflammatory response