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However, these findings are constrained by the small sample sizes and considerable heterogeneity among the included trials [219]

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(3) M Bex, R Abs, D Maiter, et al (2002) The effects of growth hormone replacement therapy on bone metabolism in adult-onset growth hormone deficiency: a 2-year open randomized controlled multicenter trial – Journal of Bone Mineral Research, 2002 Jun, Volume 17 (Issue 6), Pages 1081-94