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Furthermore, studies also showed that PEITC inhibits the formation of 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB) releasing DNA adducts of NNK and BaP [206–209]

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Inhibition of key regulators of Gln utilization, such as GLS and MYC, or reduced Gln consumption, has been shown to increase the radiosensitivity of PCa cells, diminish CSC formation in vivo , and decrease tumor development in xenograft mouse models