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Some molecular mechanism of resveratrol action include inhibition of prohypertrophic signaling molecules, improvement of myocardial Ca 2+ handling, phosphorylation of prosurvival (Akt-1, GSK-3 β ) and stress signaling (MKP-1) pathways and the reduction of oxidative stress and inflammation (iNOS, COX-2 activity, and ROS formation) [75]