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3.4.1 PD-1/PD-L1 In the realm of immune combination therapies targeting microenvironment remodeling and therapeutic efficacy heterogeneity, Bevacizumab enhances the T-cell cytotoxic effects of PD-1/PD-L1 inhibitors by mitigating the VEGF-driven immunosuppressive microenvironment, which includes reducing the infiltration of regulatory T cells and MDSCs (Jain, 2005)