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Frontiers | The association of vitamin deficiency with depression risk in late-life depression: a review

Deficiency is common in those with fatigue, brain fog, or nutrient absorption issues, especially individuals with gastrointestinal conditions, vegans and vegetarians, or those taking medications like metformin or proton-pump inhibitors

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Laboratory applications may include enzyme-inhibition assays, molecular pathway characterization, analytical comparison, and other controlled experimental models involving NNMT- and NAD⁺-associated processes