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Patients taking bupropion for smoking cessation may also experience changes in mood, psychosis, hallucinations, paranoia, delusions, homicidal ideation, hostility, aggression, anxiety, and panic, as well as suicidal ideation, suicide attempt, and completed suicide, high blood pressure, fast, irregular heartbeats, seizures, acute angle-closure glaucoma, and death

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Indeed, when looking at the corresponding regions 39 and 40 (to a lesser extent, the Atlantic region 7), it is clear that this typical model behaviour can explain the poor temporal correlation