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A structure-based assignment of the glutathione activator site without transition-state analogues is much more difficult because of labile GSH interactions 2 that likely depend not only on the presence of the first glutathione moiety but also on conformational changes of the glutathionylated enzyme 3,12,37,44

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In participants without type 2 diabetes, the highest doses (8 mg and 12 mg) were associated with mean reductions in body weight of approximately 17% at 24 weeks